20.500.12556/ReVIS-12633 Maternal gut microbiota in gestational diabetes mellitus and fetal macrosomia is there an association? Background/Objectives: Gestational diabetes mellitus (GDM) is associated with altered maternal gut microbiota and increased risk of large-for-gestational age (LGA) births. The contribution of gut microbiota to fetal overgrowth in GDM, independent of glycemic control, remains unclear. Methods: In this pilot longitudinal study, the gut microbiota of 18 women with GDM was followed from the second (2T) to the third trimester (3T). Maternal fecal samples were analyzed by 16S rRNA gene sequencing, and associations between microbial profiles and infant birth weight were examined. In addition, these associations were adjusted for pre-pregnancy body mass index (BMI) and gestational weight gain (GWG). Results: Maternal gut microbiota of LGA infants exhibited consistently lower microbial diversity, a reduced Bacillota/Bacteroidota ratio, and enrichment of pro-inflammatory taxa including Prevotella, Sutterella, and Bilophila. Short-chain fatty acids (SCFAs)-producing genera such as Acinetobacter, Odoribacter, Faecalibacterium, and Lachnoclostridium were depleted. Although Bilophila was identified as a third-trimester biomarker with LEfSE approach, its association with LGA disappeared after adjusting for BMI and GWG. Conversely, Nitrospirota, Polaromonas, Acinetobacter, and Aeromonas correlated negatively with LGA even after BMI and GWG adjustment. Conclusions: These findings suggest that specific maternal microbiota signatures, together with pre-pregnancy adiposity, influence fetal overgrowth in GDM and may serve as early biomarkers or targets for preventive interventions. gut microbiota gestational diabetes large for gestational age infants gestational weight gain črevesna mikrobiota gestacijski diabetes velik otrok za gestacijsko starost pridobitev teže med nosečnostjo true false false Angleški jezik Slovenski jezik Neznano 2025-12-09 09:44:30 2025-12-09 09:44:31 2025-12-10 03:05:48 0000-00-00 00:00:00 2025 0 0 Soavtorji: Katja Molan, Draženka Pongrac Barlovič, Marjanca Starčič Erjavec, Darja Žgur Bertok, Jerneja Ambrožič Avguštin; Nasl. z nasl. zaslona; Opis vira z dne 9. 12. 2025; str. 1-17 iss. 12, [article no.] 2941 Vol. 13 2025 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 2025-01-01 616.379-008.64-055.26 2227-9059 260546051 10.3390/biomedicines13122941 https://www.mdpi.com/2227-9059/13/12/2941 1 489796da-d4db-11f0-94a7-001a4af901a5 https://revis.openscience.si/Dokument.php?lang=slv&id=14827 RAZ_Pasic_Lejla_2025.pdf RAZ_Pasic_Lejla_2025.pdf 1 9D9AD89C7A90B877F471483080C96F12 3d0b75dbc3a04253af1b191b7eff541631954908bb26a99ae1c70fc0038632ee 7b524341-d4db-11f0-94a7-001a4af901a5 https://revis.openscience.si/Dokument.php?lang=slv&id=14828 Univerza v Novem mestu - Fakulteta za zdravstvene vede 0 0 0